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The explosive growth in supercomputers capacity has changed simulation paradigms. Simulations have shifted from a few lengthy ones to an ensemble of multiple simulations with varying initial conditions or input parameters. Thus, an ensemble consists of large volumes of multi-dimensional data that could go beyond the exascale boundaries. However, the disparity in growth rates between storage capabilities and computing resources results in I/O bottlenecks. This makes it impractical to utilize conventional postprocessing and visualization tools for analyzing such massive simulation ensembles. In situ visualization approaches alleviate I/O constraints by saving predetermined visualizations in image databases during simulation. Nevertheless, the unavailability of output raw data restricts the flexibility of post hoc exploration of in situ approaches. Much research has been conducted to mitigate this limitation, but it falls short when it comes to simultaneously exploring and analyzing parameter and ensemble spaces. In this paper, we propose an expert-in-the-loop visual exploration analytic approach. The proposed approach leverages: feature extraction, deep learning, and human expert–AI collaboration techniques to explore and analyze image-based ensembles. Our approach utilizes local features and deep learning techniques to learn the image features of ensemble members. The extracted features are then combined with simulation input parameters and fed to the visualization pipeline for in-depth exploration and analysis using human expert + AI interaction techniques. We show the effectiveness of our approach using several scientific simulation ensembles.